Inclusion Criteria

• Documented diagnosis of CD with a minimum disease duration of 3 months
• Daily stool frequency
• Endoscopic evidence of active disease as measured by SES-CD Total score
• Wash out 6-8 weeks

Exclusion Criteria

• Symptomatic strictures, OR
• Severe (impassable) rectal/anal stenosis, OR
• Fistulae, OR
• Short bowel syndrome, OR
• Have any current abscesses or infections
• History of malignancy within the last 5 years, except non-melanoma skin cancer

• 18 and over
• Diagnosis of CD
• No UC or indeterminate colitis
• No investigational agents within 30 days of screening that is part of a double-blinded study

Inclusion Criteria:

• Must have been diagnosed for at least 3 months.
• Tried 5-ASA, Steroids, immunomodulators and/or biologics and either failed, lost response or been intolerant.
• Must be willing to use highly effective birth control.
• Disease at least 15 to 20 cm from the anal verge, no Proctitis only.
• Must be symptomatic with rectal bleeding and increased diarrhea.

Exclusion Criteria

• Indeterminate Colitis or Crohn’s must be definitively UC
• No colon resections/surgeries for UC
• No chronic NSAID use
• No C. diff. currently or recent Live vaccines
• No current Anemia, must be Hgb >9g/dL
• Wash out 6-8 weeks

Inclusion Criteria:

• 18-75 years of age
• F2-F4 fibrosis by fibroscan and NAFLD Score
• No change in medication for diabetes, hypertension or hyperlipidemia; or change in Vitamin E for 6 months prior to diagnostic liver biopsy/screening.

Exclusion Criteria

• History of decompensation
• AST/ALT ≥ 5 x Upper Limit of Normal
• Platelets ≤100,000/ mm3
• Prior or planned bariatric surgery
• History of cancer, cardiovascular or cerebrovascular event within last 5 years

Inclusion Criteria:

• Recurrent C-Diff – 1 -2 recurrence; can be on antibiotics at time of referral
• Positive stool test for diff within 30 days prior to enrollment
• Currently taking or was just prescribed antibiotics to control CDI-related diarrhea at the time of enrollment (CDI diarrhea must be controlled <3 unformed/loose stools/day).
• Willing and able to have enemas

Exclusion Criteria

• Currently has continued CDI diarrhea despite being on a course of CDI antibiotic treatment.
• History of IBD, IBS, ostomy, chronic diarrhea, celiac disease or any disease requiring antibiotic therapy.
• Previous fecal transplant, RBX2660 treatment, receipt of CDI vaccine
• ANC <1000 cells/µL

Cohort B:

• Patients 50-84 who have had not had a colonoscopy in the past 9 years
• Cannot have a hx of copo (unless hyperplastic only) or coca
• Cannot have IBD or previous hx of bowel resection
• Cannot have 2+ immediate family members diagnosed with CRC

Cohort A & C:

• Looking for patients newly diagnosed with Colorectal cancer via colonoscopy report and pathology report.
• Need to be enrolled before surgery.

• 40 years or older
• DX of CRC at any stage confirmed by tissue biopsy or colorectal lesion at least 1 cm in size
• No previous cancer diagnosis

• 18-75 years old
• Document Liver biopsy (no cirrhosis)
• History of ALP above ULN for at least 6 months
• No prior TX with OCA

Please call (318) 525-3233 for more information. Updated 3/6/19