Yes, IBD treatment has evolved significantly in the last 20 years. Fifteen years ago, there were only three or four drugs available to treat Crohn’s and Ulcerative Colitis. Right now, we have more than 20 in the market. On top of that, we have another six or seven drugs in clinical trials and that have made the treatment more available. The serious side effects that were mentioned initially are considered safer at this time, and we believe that the benefits of these trials and treatments greatly exceed the potential risks associated with these medications.